| Active Players |
| 11 | Aiyuk, Brandon | WR | 03/17/1998 | 22 | 6' 00" | 205 | Arizona State | SF | 20 01 025 | R |
| 51 | Al-Shaair, Azeez | IB | 08/04/1997 | 23 | 6' 02" | 231 | Florida Atlantic | SF FA | 19 CFA | 2 |
| 56 | Alexander, Kwon | OB | 08/03/1994 | 26 | 6' 01" | 227 | LSU | TB | 15 04 124 | 6 |
| 91 | Armstead, Arik | DE | 11/15/1993 | 26 | 6' 07" | 292 | Oregon | SF | 15 01 017 | 6 |
| 3 | Beathard, CJ | QB | 11/16/1993 | 26 | 6' 03" | 219 | Iowa | SF | 17 03 104 | 4 |
| 97 | Bosa, Nick | DE | 10/23/1997 | 22 | 6' 04" | 266 | Ohio State | SF | 19 01 002 | 2 |
| 84 | Bourne, Kendrick | WR | 08/04/1995 | 25 | 6' 02" | 190 | Eastern Washington | SF FA | 17 CFA | 4 |
| 60 | Brunskill, Daniel | OT | 01/27/1994 | 26 | 6' 05" | 260 | San Diego State | ATL FA | 17 CFA | 2 |
| 26 | Coleman, Tevin | RB | 04/16/1993 | 27 | 5' 11" | 206 | Indiana | ATL | 15 03 073 | 6 |
| 66 | Compton, Tom | OT | 05/10/1989 | 31 | 6' 05" | 314 | South Dakota | WAS | 12 06 193 | 8 |
| 82 | Dwelley, Ross | TE | 01/26/1995 | 25 | 6' 04" | 240 | San Diego | SF FA | 18 CFA | 3 |
| 45 | Flannigan-Fowles, Demetrius | SS | 01/01/1990 | 30 | 6' 02" | 205 | Arizona | SF FA | 19 CFA | 1 |
| 55 | Ford, Dee | DE | 03/19/1991 | 29 | 6' 02" | 252 | Auburn | KC | 14 01 023 | 7 |
| 63 | Garland, Ben | OG | 04/06/1988 | 32 | 6' 05" | 275 | Air Force | DEN FA | 10 CFA | 7 |
| 10 | Garoppolo, Jimmy | QB | 11/02/1991 | 28 | 6' 02" | 226 | Eastern Illinois | NE | 14 02 062 | 7 |
| 90 | Givens, Kevin | DT | 03/01/1997 | 23 | 6' 01" | 285 | Penn State | SF FA | 19 CFA | 1 |
| 9 | Gould, Robbie | PK | 12/30/1981 | 38 | 6' 00" | 185 | Penn State | NE FA | 05 CFA | 16 |
| 57 | Greenlaw, Dre | IB | 05/25/1997 | 23 | 5' 11" | 237 | Arkansas | SF | 19 05 148 | 2 |
| 36 | Harris, Marcell | SS | 06/09/1994 | 26 | 6' 01" | 216 | Florida | SF | 18 06 184 | 3 |
| 92 | Hyder, Kerry | DE | 05/02/1991 | 29 | 6' 02" | 290 | Texas Tech | NYJ FA | 14 CFA | 5 |
| 27 | Johnson, Dontae | FS | 12/01/1991 | 28 | 6' 02" | 200 | North Carolina St | SF | 14 04 129 | 6 |
| 93 | Jones, DJ | DT | 01/19/1995 | 25 | 6' 01" | 319 | Mississippi | SF | 17 06 198 | 4 |
| 44 | Juszczyk, Kyle | FB | 04/23/1991 | 29 | 6' 01" | 248 | Harvard | BAL | 13 04 130 | 8 |
| 99 | Kinlaw, Javon | DT | 10/03/1997 | 22 | 6' 05" | 324 | South Carolina | SF | 20 01 014 | R |
| 85 | Kittle, George | TE | 10/09/1993 | 26 | 6' 04" | 247 | Iowa | SF | 17 05 146 | 4 |
| 69 | McGlinchey, Mike | OT | 01/12/1995 | 25 | 6' 08" | 309 | Notre Dame | SF | 18 01 009 | 3 |
| 28 | McKinnon, Jerick | RB | 05/03/1992 | 28 | 5' 09" | 209 | Georgia Southern | MIN | 14 03 096 | 7 |
| 68 | McKivitz, Colton | OT | 08/09/1996 | 24 | 6' 06" | 306 | West Virginia | SF | 20 05 153 | R |
| 33 | Moore, Tarvarius | FS | 08/16/1996 | 24 | 6' 01" | 189 | Southern Miss | SF | 18 03 095 | 3 |
| 41 | Moseley, Emmanuel | CB | 03/25/1996 | 24 | 5' 11" | 180 | Tennessee | SF FA | 18 CFA | 3 |
| 31 | Mostert, Raheem | RB | 04/09/1992 | 28 | 5' 11" | 190 | Purdue | PHI FA | 15 CFA | 6 |
| 4 | Mullens, Nick | QB | 03/21/1995 | 25 | 6' 01" | 199 | Southern Miss | SF FA | 17 CFA | 3 |
| 86 | Nelson, Kyle | LS | 10/03/1986 | 33 | 6' 03" | 240 | New Mexico State | NO FA | 11 CFA | 9 |
| 53 | Nzeocha, Mark | OB | 01/01/1990 | 30 | 6' 02" | 232 | Wyoming | DAL | 15 07 236 | 6 |
| 18 | Pettis, Dante | WR | 10/23/1995 | 24 | 6' 00" | 186 | Washington | SF | 18 02 044 | 3 |
| 81 | Reed, Jordan | TE | 07/03/1990 | 30 | 6' 02" | 236 | Florida | WAS | 13 03 085 | 8 |
| 14 | Sanu, Mohamed | WR | 08/22/1989 | 31 | 6' 01" | 211 | Rutgers | CIN | 12 03 083 | 9 |
| 67 | Skule, Justin | OT | 11/23/1996 | 23 | 6' 07" | 317 | Vanderbilt | SF | 19 06 183 | 2 |
| 95 | Street, Kentavius | DE | 05/08/1996 | 24 | 6' 02" | 280 | North Carolina St | SF | 18 04 128 | 2 |
| 29 | Tartt, Jaquiski | SS | 02/18/1992 | 28 | 6' 01" | 220 | Samford | SF | 15 02 046 | 6 |
| 15 | Taylor, Trent | WR | 04/30/1994 | 26 | 5' 08" | 178 | Louisiana Tech | SF | 17 05 177 | 4 |
| 94 | Thomas, Solomon | DE | 12/20/1995 | 24 | 6' 03" | 273 | Stanford | SF | 17 01 003 | 4 |
| 75 | Tomlinson, Laken | OG | 02/09/1992 | 28 | 6' 03" | 323 | Duke | DET | 15 01 028 | 6 |
| 22 | Verrett, Jason | CB | 05/13/1991 | 29 | 5' 09" | 189 | TCU | SD | 14 01 025 | 7 |
| 20 | Ward, Jimmie | SS | 07/18/1991 | 29 | 5' 11" | 193 | Northern Illinois | SF | 14 01 030 | 7 |
| 54 | Warner, Fred | IB | 11/19/1996 | 23 | 6' 03" | 236 | BYU | SF | 18 03 070 | 3 |
| 35 | Webster**, Ken | CB | 06/19/1996 | 24 | 5' 11" | 203 | Mississippi | NE | 19 07 252 | 2 |
| 24 | Williams, K'Waun | CB | 07/12/1991 | 29 | 5' 09" | 183 | Pittsburgh | CLE FA | 14 CFA | 6 |
| 71 | Williams, Trent | OT | 08/19/1988 | 32 | 6' 05" | 314 | Oklahoma | WAS | 10 01 004 | 10 |
| 30 | Wilson, Jeffery | RB | 11/16/1995 | 24 | 5' 11" | 210 | North Texas | SF FA | 18 CFA | 3 |
| 6 | Wishnowsky, Mitch | PT | 03/02/1992 | 28 | 6' 02" | 219 | Utah | SF | 19 04 110 | 2 |
| 23 | Witherspoon, Ahkello | CB | 03/21/1995 | 25 | 6' 03" | 198 | Colorado | SF | 17 03 066 | 4 |
| 89 | Woerner, Charlie | TE | 10/16/1997 | 22 | 6' 04" | 245 | Georgia | SF | 20 06 190 | R |
| Practice Squad |
| 0 | Allen, Brian | CB | 10/21/1993 | 26 | 6' 03" | 215 | Utah | PIT | 17 05 173 | 4 |
| 14 | Cracraft, River | WR | 11/01/1994 | 25 | 6' 00" | 197 | Washington State | DEN FA | 17 CFA | 2 |
| 32 | Cyprien, Jonathan | SS | 07/29/1990 | 30 | 6' 00" | 217 | Florida International | JAX | 13 02 033 | 8 |
| 65 | Daniels, Darrion | DT | 12/04/1997 | 22 | 6' 03" | 311 | Nebraska | SF FA | 20 CFA | R |
| 50 | Grasu, Hroniss | OC | 08/12/1991 | 29 | 6' 03" | 297 | Oregon | CHI | 15 03 071 | 6 |
| 83 | Harrell, Chase | TE | 05/16/1997 | 23 | 6' 04" | 228 | Arkansas | SF FA | 20 CFA | R |
| 35 | Harris, Tim | CB | 07/31/1995 | 25 | 6' 02" | 206 | Virginia | SF | 19 06 198 | 2 |
| 38 | Hasty**, JaMycal | RB | 09/12/1996 | 24 | 5' 08" | 205 | Baylor | SF FA | 20 CFA | R |
| 40 | Hokit, Josh | RB | 11/12/1997 | 22 | 6' 01" | 225 | Fresno State | SF FA | 20 CFA | R |
| 17 | Jennings, Jauan | WR | 07/10/1997 | 23 | 6' 03" | 215 | Tennessee | SF | 20 07 217 | R |
| 96 | Jordan, Dion | DE | 03/05/1990 | 30 | 6' 06" | 248 | Oregon | MIA | 13 01 003 | 6 |
| 43 | Mayden, Jared | SS | 06/24/1998 | 22 | 6' 00" | 201 | Alabama | SF FA | 20 CFA | R |
| 61 | Shepley, Dakoda | OT | 12/27/1994 | 25 | 6' 05" | 315 | British Columbia, Can | NYJ FA | 18 CFA | 1 |
| 62 | Sweet, William | OT | 04/29/1997 | 23 | 6' 07" | 300 | North Carolina | ARZ FA | 19 CFA | 2 |
| 59 | Walker, Joe | IB | 12/11/1992 | 27 | 6' 02" | 238 | Oregon | PHI | 16 07 251 | 5 |
| 88 | White, Kevin | WR | 06/25/1992 | 28 | 6' 03" | 215 | West Virginia | CHI | 15 01 007 | 5 |
| Reserves |
| 5 | Austin, Tavon | WR | 03/15/1991 | 29 | 5' 08" | 174 | West Virginia | SL | 13 01 008 | 8 |
| 17 | Benjamin, Travis | WR | 12/29/1989 | 30 | 5' 10" | 175 | Miami | CLE | 12 04 100 | 8 |
| 98 | Blair, Ronald | DE | 01/21/1993 | 27 | 6' 02" | 284 | Appalachian State | SF | 16 05 142 | 5 |
| 64 | Brendel, Jake | OC | 09/10/1992 | 28 | 6' 04" | 303 | UCLA | DAL FA | 16 CFA | 4 |
| 78 | Coleman, Shon | OT | 11/25/1991 | 28 | 6' 05" | 307 | Auburn | CLE | 16 03 076 | 4 |
| 14 | Hurd, Jalen | WR | 01/23/1996 | 24 | 6' 05" | 226 | Baylor | SF | 19 03 067 | 2 |
| 13 | James, Richie | WR | 09/05/1995 | 25 | 5' 10" | 183 | Middle Tennessee | SF | 18 07 240 | 3 |
| 58 | Richburg, Weston | OC | 07/09/1991 | 29 | 6' 03" | 298 | Colorado State | NYG | 14 02 043 | 7 |
| 19 | Samuel, Deebo | WR | 01/15/1996 | 24 | 5' 11" | 214 | South Carolina | SF | 19 02 036 | 2 |
| 25 | Sherman, Richard | CB | 03/30/1988 | 32 | 6' 03" | 195 | Stanford | SEA | 11 05 154 | 10 |
| 77 | Taylor, Jullian | DT | 01/30/1995 | 25 | 6' 05" | 240 | Temple | SF | 18 07 223 | 3 |
| 2 | Thompson, Chris | WR | 05/09/1994 | 26 | 5' 11" | 165 | Florida | HOU FA | 17 CFA | 2 |