| Pos | No | Player 1 | No | Player 2 | No | Player 3 | No | Player 4 | No | Player 5 |
| Offense |
| LWR | 11 |
Aiyuk, Brandon 20/1
| 18 |
CONLEY, CHRIS U/Ten
| |
| |
| |
|
| RWR | 1 |
Samuel Sr., Deebo 19/2
| 10 |
Bell, Ronnie 23/7
| |
| |
| |
|
| SWR | 15 |
Jennings, Jauan 20/7
| 19 |
Cowing, Jacob 24/4
| |
| |
| |
|
| LT | 71 |
WILLIAMS, TRENT T/Was
| 76 |
Moore, Jaylon 21/5
| |
| |
| |
|
| LG | 65 |
Banks, Aaron 21/2
| 74 |
Burford, Spencer 22/4
| |
| |
| |
|
| C | 64 |
BRENDEL, JAKE SF20
| 63 |
Zakelj, Nick 22/6
| |
| |
| |
|
| RG | 77 |
Puni, Dominick 24/3
| 78 |
Bartch, Ben P/Jax
| |
| |
| |
|
| RT | 68 |
McKivitz, Colton 20/5
| |
| |
| |
| |
|
| TE | 85 |
KITTLE, GEORGE 17/5
| 82 |
SAUBERT, ERIC U/Hou
| 88 |
Tonges, Jake SF23
| |
| |
|
| QB | 13 |
Purdy, Brock 22/7
| 17 |
ALLEN, BRANDON U/Cin
| 5 |
Dobbs, Joshua U/Min
| |
| |
|
| RB | 24 |
Mason, Jordan CF22
| 31 |
Guerendo, Isaac 24/4
| 32 |
Taylor Jr., Patrick U/GB
| |
| |
|
| FB | 44 |
JUSZCZYK, KYLE U/Bal
| |
| |
| |
| |
|
| Defense |
| LDE | 97 |
Bosa, Nick 19/1
| 51 |
Beal Jr., Robert 23/5
| |
| |
| |
|
| LDT | 99 |
Collins, Maliek T/Hou
| 90 |
Givens, Kevin CF19
| |
| |
| |
|
| RDT | 98 |
HARGRAVE, JAVON U/Phi
| 92 |
Elliott, Jordan U/Cle
| |
| |
| |
|
| RDE | 56 |
FLOYD, LEONARD U/Buf
| 94 |
Gross-Matos, Yetur U/Car
| |
| |
| |
|
| WLB | 59 |
CAMPBELL SR., DE'VONDRE CC/GB
| 53 |
Winters, Dee 23/6
| |
| |
| |
|
| MLB | 54 |
Warner, Fred 18/3
| 36 |
Robinson, Curtis SF21
| |
| |
| |
|
| SLB | 45 |
Flannigan-Fowles, Demetrius CF19
| 48 |
Bethune, Tatum 24/7
| |
| |
| |
|
| LCB | 7 |
Ward, Charvarius U/KC
| 33 |
Ya-Sin, Rock U/Bal
| |
| |
| |
|
| SS | 29 |
Hufanga, Talanoa 21/5
| 30 |
ODUM, GEORGE U/Ind
| |
| |
| |
|
| FS | 27 |
Brown, Ji'Ayir 23/3
| 6 |
Mustapha, Malik 24/4
| |
| |
| |
|
| RCB | 22 |
Yiadom, Isaac U/NO
| 28 |
Luter Jr., Darrell 23/5
| |
| |
| |
|
| NB | 2 |
Lenoir, Deommodore 21/5
| 0 |
Green, Renardo 24/2
| |
| |
| |
|
| Special Teams |
| PT | 3 |
WISHNOWSKY, MITCH 19/4
| |
| |
| |
| |
|
| PK | 4 |
Moody, Jake 23/3
| |
| |
| |
| |
|
| LS | 46 |
PEPPER, TAYBOR SF20
| |
| |
| |
| |
|
| H | 3 |
WISHNOWSKY, MITCH 19/4
| |
| |
| |
| |
|
| KO | 4 |
Moody, Jake 23/3
| |
| |
| |
| |
|
| PR | 19 |
Cowing, Jacob 24/4
| 10 |
Bell, Ronnie 23/7
| |
| |
| |
|
| KR | 24 |
Mason, Jordan CF22
| 10 |
Bell, Ronnie 23/7
| 31 |
Guerendo, Isaac 24/4
| |
| |
|
| Practice Squad |
| PS | 35 |
Walker III, Tracy S
| 84 |
Marshall Jr., Terrace WR
| 67 |
Alarcon, Isaac OT*
| 69 |
Anderson, Evan DT
| 89 |
Pline, Mason TE
|
| PS | 61 |
HUBBARD, CHRIS OT
| 40 |
Vaughn, Ke'Shawn RB
| 38 |
Mahoney, Jaylen S
| 4 |
Mordecai, Tanner QB
| 26 |
Lucas, Chase CB
|
| PS | 81 |
TAYLOR, TRENT WR
| 66 |
Nugent, Drake OC
| 47 |
White, DaShaun LB
| 9 |
Willis, Brayden TE
| 96 |
MCGILL, T.Y. DT
|
| PS | 91 |
Okuayinonu, Sam DE
| 58 |
BARRETT, ALEX DE
| |
| |
| |
|
| Reserves |
| IR | 23 |
McCaffrey, Christian RB^
| 55 |
FELICIANO, JON OC^
| 20 |
Thomas, Ambry CB^
| 93 |
Davis, Kalia DT^
| 25 |
Mitchell, Elijah RB
|
| PUP | 57 |
Greenlaw, Dre LB^
| 95 |
Jackson, Drake DE
| |
| |
| |
|
| NFI | 14 |
Pearsall, Ricky WR^
| |
| |
| |
| |
|