| Pos | No | Player 1 | No | Player 2 | No | Player 3 | No | Player 4 | No | Player 5 |
| Offense |
| LWR | 11 |
Aiyuk, Brandon 20/1
| 6 |
Gray, Danny 22/3
| |
| |
| |
|
| RWR | 19 |
Samuel, Deebo 19/2
| 86 |
Martin, Tay CF22
| 00 |
Johnson, Tyron SF23
| |
| |
|
| SWR | 15 |
Jennings, Jauan 20/7
| 3 |
McCloud III, Ray-Ray U/Pit
| 84 |
Newsome, Dazz SF22
| |
| |
|
| LT | 71 |
WILLIAMS, TRENT T/Was
| 78 |
Watson, Leroy SF22
| |
| |
| |
|
| LG | 65 |
Banks, Aaron 21/2
| 62 |
Poe, Jason CF22
| |
| |
| |
|
| C | 64 |
BRENDEL, JAKE SF20
| 76 |
FELICIANO, JON U/NYG
| 67 |
Ismael, Keith SF22
| |
| |
|
| RG | 74 |
Burford, Spencer 22/4
| 63 |
Zakelj, Nick 22/6
| |
| |
| |
|
| RT | 68 |
McKivitz, Colton 20/5
| 76 |
Moore, Jaylon 21/5
| 77 |
Gutierrez, Alfredo SF21
| |
| |
|
| TE | 85 |
Kittle, George 17/5
| 89 |
Woerner, Charlie 20/6
| 82 |
Dwelley, Ross CF18
| |
| |
|
| QB | 13 |
Purdy, Brock 22/7
| 5 |
Lance, Trey 21/1
| 00 |
Darnold, Sam U/Car
| |
| |
|
| RB | 23 |
McCaffrey, Christian T/Car
| 25 |
Mitchell, Elijah 21/6
| 24 |
Mason, Jordan CF22
| 32 |
Davis-Price, Tyrion 22/3
| |
|
| FB | 44 |
JUSZCZYK, KYLE U/Bal
| |
| |
| |
| |
|
| Defense |
| LDE | 00 |
Ferrell, Clelin U/LV
| 95 |
Jackson, Drake 22/2
| 58 |
Barrett, Alex SF19
| |
| |
|
| LDT | 00 |
HARGRAVE, JAVON U/Phi
| 99 |
Kinlaw, Javon 20/1
| 96 |
MCGILL, T.Y. SF22
| |
| |
|
| RDT | 91 |
Armstead, Arik 15/1
| 90 |
Givens, Kevin CF19
| 93 |
Davis, Kalia 22/6
| |
| |
|
| RDE | 97 |
Bosa, Nick 19/1
| 00 |
Bryant, Austin U/Det
| |
| |
| |
|
| WLB | 57 |
Greenlaw, Dre 19/5
| 48 |
Burks, Oren U/GB
| 40 |
McCrary-Ball, Marcelino CF22
| |
| |
|
| MLB | 54 |
Warner, Fred 18/3
| 45 |
Flannigan-Fowles, Demetrius CF19
| 59 |
Robinson, Curtis SF21
| |
| |
|
| LCB | 38 |
Lenoir, Deommodore 21/5
| 20 |
Thomas, Ambry 21/3
| 00 |
Swilling, Tre SF22
| |
| |
|
| SS | 29 |
Hufanga, Talanoa 21/5
| 41 |
Hawkins, Tayler CF22
| |
| |
| |
|
| FS | 31 |
GIPSON SR., TASHAUN U/Chi
| 30 |
Odum, George U/Ind
| |
| |
| |
|
| RCB | 7 |
Ward, Charvarius U/KC
| 26 |
Womack III, Samuel 22/5
| 43 |
Knight, Qwuantrezz CF22
| |
| |
|
| NB | 00 |
Hartsfield, Myles U/Car
| 00 |
Oliver, Isaiah U/Atl
| 00 |
Parker, A.J. SF23
| |
| |
|
| Special Teams |
| PT | 18 |
WISHNOWSKY, MITCH 19/4
| |
| |
| |
| |
|
| PK | 00 |
Gonzalez, Zane T/Car
| |
| |
| |
| |
|
| LS | 46 |
Pepper, Taybor SF20
| |
| |
| |
| |
|
| H | 18 |
WISHNOWSKY, MITCH 19/4
| |
| |
| |
| |
|
| KO | 00 |
Gonzalez, Zane T/Car
| |
| |
| |
| |
|
| PR | 3 |
McCloud III, Ray-Ray U/Pit
| 11 |
Aiyuk, Brandon 20/1
| |
| |
| |
|
| KR | 3 |
McCloud III, Ray-Ray U/Pit
| 6 |
Gray, Danny 22/3
| |
| |
| |
|
| Free Agents / Cap Casualties |
| FACC | 00 |
MATTHEWS, JORDAN UFA
| 00 |
VERRETT, JASON UFA
| 00 |
JOHNSON, JOSH UFA
| 00 |
GOULD, ROBBIE UFA
| 00 |
KROFT, TYLER UFA
|
| FACC | 00 |
HYDER JR., KERRY UFA
| |
| |
| |
| |
|