| Active Players |
| 48 | Adams, Tyrell | LB | 04/11/1992 | 29 | 6' 02" | 225 | West Georgia | SEA FA | 15 CFA | 4 |
| 97 | Addison, Mario | DE | 09/06/1987 | 33 | 6' 03" | 254 | Troy | CHI FA | 11 CFA | 10 |
| 17 | Allen, Josh | QB | 05/21/1996 | 25 | 6' 05" | 237 | Wyoming | BUF | 18 01 007 | 3 |
| 66 | Anderson, Jack | OG | | | 6' 05" | 309 | Texas Tech | BUF | 21 07 236 | R |
| 51 | Ankou, Eli | DT | 06/08/1994 | 27 | 6' 03" | 331 | UCLA | HOU FA | 17 CFA | 4 |
| 96 | Basham Jr., Carlos "Boogie" | DE | 12/16/1997 | 23 | 6' 03" | 281 | Wake Forest | BUF | 21 02 061 | R |
| 2 | Bass, Tyler | PK | 02/14/1997 | 24 | 5' 10" | 185 | Georgia Southern | BUF | 20 06 188 | 2 |
| 71 | Bates, Ryan | OG | 02/14/1997 | 24 | 6' 04" | 306 | Penn State | PHI FA | 19 CFA | 2 |
| 11 | Beasley, Cole | WR | 04/26/1989 | 32 | 5' 08" | 177 | SMU | DAL FA | 12 CFA | 9 |
| 84 | Becker, Nate | TE | 03/24/1996 | 25 | 6' 05" | 264 | Miami (OH) | DET FA | 19 CFA | 1 |
| 43 | Bell, Mike | FS | | | 6' 03" | 210 | Fresno State | BUF FA | 20 SFA | 0 |
| 65 | Boettger, Ike | OT | 10/05/1994 | 26 | 6' 06" | 307 | Iowa | BUF FA | 18 CFA | 3 |
| 22 | Breida, Matt | RB | 02/28/1995 | 26 | 5' 09" | 180 | Georgia Southern | SF FA | 17 CFA | 4 |
| 79 | Brown, Spencer | OT | | | 6' 08" | 314 | Northern Iowa | BUF | 21 03 093 | R |
| 90 | Bryant, Brandin | DT | 09/16/1993 | 27 | 6' 02" | 287 | Florida Atlantic | SEA FA | 16 CFA | 1 |
| 94 | Butler, Vernon | DT | 06/14/1994 | 27 | 6' 04" | 323 | Louisiana Tech | CAR | 16 01 030 | 5 |
| 13 | Davis, Gabriel | WR | 04/01/1999 | 22 | 6' 02" | 216 | Central Florida | BUF | 20 04 128 | 2 |
| 73 | Dawkins, Dion | OG | 04/26/1994 | 27 | 6' 04" | 317 | Temple | BUF | 17 02 063 | 4 |
| 64 | Devey, Jordan | OT | 01/11/1988 | 33 | 6' 07" | 317 | Memphis | BAL FA | 13 CFA | 6 |
| 14 | Diggs, Stefon | WR | 11/29/1993 | 27 | 6' 00" | 195 | Maryland | MIN | 15 05 146 | 6 |
| 53 | Dodson, Tyrel | OB | 06/25/1998 | 23 | 6' 00" | 237 | Texas A&M | BUF FA | 19 CFA | 1 |
| 77 | Douglas, Jamil | OG | 02/28/1992 | 29 | 6' 04" | 304 | Arizona State | MIA | 15 04 114 | 3 |
| 72 | Doyle, Tommy | OT | | | 6' 08" | 318 | Miami University | BUF | 21 05 161 | R |
| 49 | Edmunds, Tremaine | IB | 05/02/1998 | 23 | 6' 04" | 253 | Virginia Tech | BUF | 18 01 016 | 3 |
| 57 | Epenesa, AJ | DE | 09/15/1998 | 22 | 6' 05" | 275 | Iowa | BUF | 20 02 054 | 2 |
| 76 | Feliciano, Jon | OG | 02/10/1992 | 29 | 6' 04" | 323 | Miami | OAK | 15 04 128 | 6 |
| 69 | Ferguson, Reid | LS | 03/24/1994 | 27 | 6' 01" | 243 | LSU | BUF FA | 16 CFA | 4 |
| 74 | Ford, Cody | OG | 12/28/1996 | 24 | 6' 04" | 329 | Oklahoma | BUF | 19 02 038 | 2 |
| 4 | Fromm, Jake | QB | 07/30/1998 | 23 | 6' 02" | 219 | Georgia | BUF | 20 05 167 | 2 |
| 87 | Gentry, Tanner | WR | 12/18/1994 | 26 | 6' 01" | 211 | Wyoming | CHI FA | 17 CFA | 1 |
| 42 | Giles-Harris, Joe | IB | 04/01/1997 | 24 | 6' 02" | 234 | Duke | JAX FA | 19 CFA | 1 |
| 81 | Gilliam, Reggie | TE/FB | 08/20/1997 | 23 | 6' 01" | 255 | Toledo | BUF FA | 20 CFA | 2 |
| 63 | Gonzalez, Steven | OG | 05/11/1997 | 24 | 6' 03" | 332 | Penn State | ARZ FA | 20 CFA | 1 |
| 37 | Griffin, Olaijah | CB | | | 6' 00" | 175 | USC | BUFÂ FA | 21 CFA | R |
| 3 | Haack, Matt | PT | 07/25/1994 | 27 | 6' 01" | 199 | Arizona State | MIA FA | 17 CFA | 4 |
| 31 | Hamlin, Damar | SS | 03/24/1998 | 23 | 6' 01" | 201 | Pittsburgh | BUF | 21 06 212 | R |
| 68 | Hart, Bobby | OG | 08/21/1994 | 26 | 6' 05" | 336 | Florida State | NYG | 15 07 226 | 6 |
| 62 | Hester, Treyvon | DT | 09/21/1992 | 28 | 6' 02" | 300 | Toledo | OAK | 17 07 244 | 4 |
| 16 | Hodgins, Isaiah | WR | 10/21/1998 | 22 | 6' 04" | 210 | Oregon State | BUF | 20 06 207 | 2 |
| 80 | Hollister, Jacob | TE | 11/18/1993 | 27 | 6' 04" | 239 | Wyoming | NE FA | 17 CFA | 4 |
| 55 | Hughes, Jerry | OLB | 08/13/1988 | 32 | 6' 02" | 255 | TCU | IND | 10 01 031 | 11 |
| 23 | Hyde, Micah | CB | 12/31/1990 | 30 | 6' 00" | 197 | Iowa | GB | 13 05 159 | 8 |
| 30 | Jackson, Dane | CB | 11/29/1996 | 24 | 6' 00" | 187 | Pittsburgh | BUF | 20 07 239 | 1 |
| 92 | Johnson, Darryl | DE | 04/04/1997 | 24 | 6' 06" | 253 | North Carolina A&T | BUF | 19 07 225 | 2 |
| 46 | Johnson, Jaquan | SS | 11/13/1995 | 25 | 5' 10" | 191 | Miami | BUF | 19 06 181 | 2 |
| 24 | Johnson, Taron | CB | 07/27/1996 | 25 | 5' 11" | 192 | Weber State | BUF | 18 04 121 | 3 |
| 25 | Jones, Taiwan | RB | 07/26/1988 | 33 | 6' 00" | 194 | Eastern Washington | OAK | 11 04 125 | 10 |
| 54 | Klein, AJ | OLB | 07/30/1991 | 30 | 6' 01" | 250 | Iowa State | CAR | 13 05 148 | 8 |
| 88 | Knox, Dawson | TE | 11/14/1996 | 24 | 6' 04" | 254 | Mississippi | BUF | 19 03 096 | 2 |
| 15 | Kumerow, Jake | WR | 02/17/1992 | 29 | 6' 04" | 202 | Wisconsin-Whitewater | CIN FA | 15 CFA | 2 |
| 70 | Lamp, Forrest | OG | 02/20/1994 | 27 | 6' 04" | 309 | Western Kentucky | LAC | 17 02 038 | 4 |
| 52 | Lee, Marquel | OB | 10/21/1995 | 25 | 6' 03" | 230 | Wake Forest | OAK | 17 05 168 | 3 |
| 9 | Lenoir, Lance | WR | 02/09/1995 | 26 | 6' 00" | 199 | Western Illinois | DAL FA | 17 CFA | 3 |
| 47 | Lewis, Cameron | CB | 04/13/1997 | 24 | 5' 09" | 186 | Buffalo | BUF FA | 19 CFA | 1 |
| 98 | Lotulelei, Star | NT | 12/20/1989 | 31 | 6' 02" | 311 | Utah | CAR | 13 01 014 | 7 |
| 56 | Love, Mike | DE | 01/22/1994 | 27 | 6' 03" | 265 | South Florida | BUF FA | 18 CFA | 2 |
| 44 | Matakevich, Tyler | IB | 12/22/1992 | 28 | 6' 00" | 238 | Temple | PIT | 16 07 246 | 5 |
| 38 | McCloud, Nick | CB | | | 6' 00" | 191 | Notre Dame | BUF FA | 21 CFA | R |
| 19 | McKenzie, Isaiah | WR | 04/09/1995 | 26 | 5' 07" | 173 | Georgia | DEN | 17 05 172 | 4 |
| 58 | Milano, Matt | OB | 03/17/1995 | 26 | 6' 00" | 216 | Boston College | BUF | 17 05 163 | 4 |
| 85 | Morris, Quintin | TE | | | 6' 02" | 243 | Bowling Green | BUF FA | 21 CFA | R |
| 60 | Morse, Mitch | OT | 04/21/1992 | 29 | 6' 05" | 305 | Missouri | KC | 15 02 049 | 6 |
| 20 | Moss, Zack | RB | 12/15/1997 | 23 | 5' 09" | 223 | Utah | BUF | 20 03 086 | 2 |
| 33 | Neal, Siran | SS | 08/04/1994 | 26 | 6' 00" | 206 | Jacksonville State | BUF | 18 05 154 | 3 |
| 93 | Obada, Efe | DE/TE | 04/13/1992 | 29 | 6' 06" | 255 | no college | DAL FA | 15 SFA | 2 |
| 91 | Oliver, Ed | DT | 12/12/1997 | 23 | 6' 02" | 287 | Houston | BUF | 19 01 009 | 2 |
| 99 | Phillips, Harrison | DT | 01/25/1996 | 25 | 6' 03" | 307 | Stanford | BUF | 18 03 096 | 3 |
| 18 | Powell, Brandon | WR | 09/12/1996 | 24 | 5' 08" | 186 | Florida | DET FA | 18 CFA | 3 |
| 21 | Poyer, Jordan | CB | 04/25/1991 | 30 | 6' 00" | 191 | Oregon State | PHI | 13 07 218 | 8 |
| 50 | Rousseau, Gregory | DE | 04/05/2000 | 21 | 6' 06" | 260 | Miami | BUF | 21 01 030 | R |
| 1 | Sanders, Emmanuel | WR | 03/17/1987 | 34 | 5' 11" | 180 | SMU | PIT | 10 03 082 | 11 |
| 26 | Singletary, Devin | RB | 09/03/1997 | 23 | 5' 07" | 203 | Florida Atlantic | BUF | 19 03 074 | 2 |
| 59 | Smith, Andre | IB | 04/20/1997 | 24 | 6' 00" | 237 | North Carolina | CAR | 18 07 234 | 3 |
| 5 | Stevenson, Marquez | WR | | | 5' 10" | 182 | Houston | BUF | 21 06 203 | R |
| 89 | Sweeney, Tommy | TE | 07/01/1995 | 26 | 6' 04" | 251 | Boston College | BUF | 19 07 228 | 2 |
| 36 | Thomas, Josh | SS | 11/19/1996 | 24 | 6' 00" | 205 | Appalachian State | BUF FA | 20 CFA | 1 |
| 41 | Thompson, Tariq | SS | 08/09/1999 | 21 | 5' 11" | 197 | San Diego State | BUF FA | 21 CFA | R |
| 10 | Trubisky, Mitchell | QB | 08/20/1994 | 26 | 6' 02" | 222 | North Carolina | CHI | 17 01 002 | 4 |
| 67 | Tuitele, Syrus | OT | | | 6' 05" | 315 | Fresno State | BUF FA | 21 CFA | R |
| 45 | Wade, Christian | RB | 05/15/1991 | 30 | 5' 08" | 190 | No College | BUF FA | 19 SFA | 1 |
| 39 | Wallace, Levi | CB | 06/12/1995 | 26 | 6' 00" | 179 | Alabama | BUF FA | 18 CFA | 3 |
| 7 | Webb, Davis | QB | 01/22/1995 | 26 | 6' 05" | 229 | California | NYG | 17 03 087 | 3 |
| 27 | White, Tre'Davious | CB | 01/16/1995 | 26 | 5' 11" | 191 | LSU | BUF | 17 01 027 | 4 |
| 32 | Wildgoose, Rachad | CB | | | 5' 11" | 197 | Wisconsin | BUF | 21 06 213 | R |
| 28 | Williams, Antonio | RB | 10/22/1997 | 23 | 5' 10" | 215 | North Carolina | BUF FA | 20 CFA | 1 |
| 75 | Williams, Daryl | OT | 08/31/1992 | 28 | 6' 05" | 327 | Oklahoma | CAR | 15 04 102 | 6 |
| 82 | Williams, Duke | WR | 05/13/1992 | 29 | 6' 02" | 224 | Auburn | LA FA | 16 CFA | 2 |
| 61 | Zimmer, Justin | DT | 10/23/1992 | 28 | 6' 03" | 292 | Ferris State | BUF FA | 16 CFA | 2 |
| Reserves |
| 51 | Cox Jr., Bryan | DE | 06/25/1994 | 27 | 6' 03" | 265 | Florida | CAR FA | 17 CFA | 4 |