| Active Players |
| 71 | Akingbesote, Tommy | DT | 02/25/2003 | 23 | 6' 04" | 316 | Maryland | DAL | 25 07 247 | 1 |
| 23 | Alford, Dee | CB | 11/05/1997 | 28 | 5' 11" | 180 | Tusculum | ATL FA | 22 SFA | 5 |
| 17 | Allen, Josh | QB | 05/21/1996 | 29 | 6' 05" | 237 | Wyoming | BUF | 18 01 007 | 9 |
| 11 | Allen, Kyle | QB | 03/08/1996 | 30 | 6' 03" | 210 | Houston | CAR FA | 18 CFA | 8 |
| 70 | Anderson, Alec | C/OG | 10/03/1999 | 26 | 6' 05" | 305 | UCLA | BUF FA | 22 CFA | 4 |
| 44 | Andreessen, Joe | ILB | 02/07/2000 | 26 | 6' 01" | 240 | Buffalo | BUF FA | 24 CFA | 3 |
| 16 | Bass, Tyler | PK | 02/14/1997 | 29 | 5' 10" | 183 | Georgia Southern | BUF | 20 06 188 | 7 |
| 47 | Benford, Christian | CB | 09/21/2000 | 25 | 6' 00" | 205 | Villanova | BUF | 22 06 185 | 5 |
| 8 | Bernard, Terrel | ILB | 05/07/1999 | 26 | 6' 00" | 224 | Baylor | BUF | 22 03 089 | 5 |
| 24 | Bishop, Cole | S | 10/24/2002 | 23 | 6' 02" | 206 | Utah | BUF | 24 02 060 | 3 |
| Broeker, Nick | OG | 10/07/2000 | 25 | 6' 04" | 305 | Mississippi | BUF | 23 07 230 | 3 |
| 79 | Brown, Spencer | OT | 02/28/1998 | 28 | 6' 08" | 311 | Northern Iowa | BUF | 21 03 093 | 6 |
| 6 | Buechele, Shane | QB | 01/08/1998 | 28 | 6' 00" | 210 | SMU | KC FA | 21 CFA | 4 |
| 90 | Carter, DeWayne | DT | 12/10/2000 | 25 | 6' 02" | 302 | Duke | BUF | 24 03 095 | 3 |
| 9 | Chubb, Bradley | OLB | 06/24/1996 | 29 | 6' 04" | 268 | North Carolina State | DEN | 18 01 005 | 9 |
| 35 | Ciarlo, Jimmy | ILB | 02/28/2001 | 25 | 6' 01" | 225 | Army | NYJ FA | 24 CFA | 2 |
| 67 | Clayton, Travis | OT | 02/17/2001 | 25 | 6' 07" | 303 | No College | BUF | 24 07 221 | 2 |
| 0 | Coleman, Keon | WR | 05/17/2003 | 22 | 6' 03" | 213 | Florida State | BUF | 24 02 033 | 3 |
| 4 | Cook III, James | RB | 09/25/1999 | 26 | 5' 11" | 190 | Georgia | BUF | 22 02 063 | 5 |
| 33 | Couch, Te'Cory | CB | 09/06/1999 | 26 | 5' 10" | 185 | Miami | BUF FA | 24 CFA | 1 |
| 7 | Davis, Ray | RB | 11/11/1999 | 26 | 5' 08" | 211 | Kentucky | BUF | 24 04 128 | 3 |
| 73 | Dawkins, Dion | OT | 04/26/1994 | 31 | 6' 04" | 320 | Temple | BUF | 17 02 063 | 10 |
| 38 | Devonshire, MJ | CB | 09/12/2000 | 25 | 5' 11" | 186 | Pittsburgh | LV | 24 07 229 | 1 |
| 69 | Ferguson, Reid | LS | 03/24/1994 | 31 | 6' 01" | 235 | LSU | BUF FA | 16 CFA | 10 |
| 28 | Franklin Jr., Sam | S | 02/02/1996 | 30 | 6' 03" | 210 | Temple | CAR FA | 20 CFA | 7 |
| 22 | Gardner-Johnson, C.J. | S | 12/20/1997 | 28 | 5' 11" | 208 | Florida | NO | 19 04 105 | 8 |
| 20 | Gore Jr., Frank | RB | 03/13/2002 | 24 | 5' 08" | 201 | Southern Miss | BUF FA | 24 CFA | 1 |
| 89 | Gosnell, Stephen | WR | 10/22/2001 | 24 | 6' 02" | 198 | Virginia Tech | BUF FA | 25 CFA | 1 |
| 68 | Grable, Tylan | OT/OG | 10/04/1999 | 26 | 6' 06" | 313 | Central Florida | BUF | 24 06 204 | 3 |
| 31 | Hairston, Maxwell | CB | 08/06/2003 | 22 | 6' 00" | 192 | Kentucky | BUF | 25 01 030 | 2 |
| 37 | Hancock, Jordan | S | 08/12/2003 | 22 | 6' 00" | 195 | Ohio State | BUF | 25 05 170 | 2 |
| 1 | Hardman Jr., Mecole | WR | 03/12/1998 | 28 | 5' 10" | 187 | Georgia | KC | 19 02 056 | 8 |
| 85 | Hawes, Jackson | TE | 12/06/2000 | 25 | 6' 04" | 253 | Georgia Tech | BUF | 25 05 173 | 2 |
| 55 | Hoecht, Michael | OLB | 10/05/1997 | 28 | 6' 04" | 264 | Brown | LAR FA | 20 CFA | 6 |
| 94 | Jackson, Landon | DE | 01/02/2003 | 23 | 6' 06" | 264 | Arkansas | BUF | 25 03 072 | 2 |
| 49 | Jenkins, Keonta | ILB | 01/26/2002 | 24 | 6' 02" | 211 | Virginia Tech | BUF FA | 25 CFA | 1 |
| 26 | Johnson, Ty | RB | 09/17/1997 | 28 | 5' 10" | 210 | Maryland | DET | 19 06 186 | 8 |
| 75 | Jones Jr., Andre | OLB | 10/25/1998 | 27 | 6' 04" | 258 | Louisiana | WAS | 23 07 233 | 2 |
| 86 | Kincaid, Dalton | TE | 10/18/1999 | 26 | 6' 04" | 246 | Utah | BUF | 23 01 025 | 4 |
| 88 | Knox, Dawson | TE | 11/14/1996 | 29 | 6' 04" | 254 | Mississippi | BUF | 19 03 096 | 8 |
| 83 | Latu, Keleki | TE | 08/13/2002 | 23 | 6' 06" | 249 | Washington | BUF FA | 25 CFA | 1 |
| 93 | Logue, Zion | DT | 07/13/2001 | 24 | 6' 06" | 325 | Georgia | ATL | 24 06 197 | 1 |
| 77 | Lundt, Chase | OT | 06/16/2000 | 25 | 6' 07" | 304 | Connecticut | BUF | 25 06 206 | 2 |
| 72 | Mathis, Phidarian | DE | 04/26/1998 | 27 | 6' 04" | 312 | Alabama | WAS | 22 02 047 | 5 |
| 66 | McGovern, Connor | C/OG | 11/03/1997 | 28 | 6' 05" | 318 | Penn State | DAL | 19 03 090 | 8 |
| 2 | Moore, DJ | WR | 04/14/1997 | 28 | 6' 00" | 213 | Maryland | CAR | 18 01 024 | 9 |
| 91 | Oliver, Ed | DT | 12/12/1997 | 28 | 6' 02" | 287 | Houston | BUF | 19 01 009 | 8 |
| 30 | Owens, Wande | S | 03/26/2001 | 24 | 5' 11" | 205 | New Hampshire | BUF FA | 25 CFA | 2 |
| 5 | Palmer, Joshua | WR | 09/22/1999 | 26 | 6' 01" | 210 | Tennessee | LAC | 21 03 077 | 6 |
| 46 | Porter Jr., Daryl | CB | 02/03/2002 | 24 | 5' 11" | 184 | Miami | BUF FA | 25 CFA | 1 |
| 15 | Rousseau, Greg | OLB | 04/05/2000 | 25 | 6' 06" | 266 | Miami | BUF | 21 01 030 | 6 |
| 98 | Sanders, T.J. | DE | 07/30/2003 | 22 | 6' 04" | 297 | South Carolina | BUF | 25 02 041 | 2 |
| 10 | Shakir, Khalil | WR | 02/03/2000 | 26 | 6' 00" | 190 | Boise State | BUF | 22 05 148 | 5 |
| 14 | Shavers, Tyrell | WR | 08/18/1999 | 26 | 6' 04" | 211 | San Diego State | BUF FA | 23 CFA | 2 |
| 56 | Solomon, Javon | OLB | 01/17/2001 | 25 | 6' 01" | 246 | Troy | BUF | 24 05 168 | 3 |
| Stone, Geno | S | 04/19/1999 | 26 | 5' 10" | 210 | Iowa | BAL | 20 07 219 | 6 |
| 43 | Strong, Dorian | CB | 03/14/2002 | 24 | 6' 01" | 185 | Virginia Tech | BUF | 25 06 177 | 2 |
| 64 | Torrence, O'Cyrus | OG | 01/20/2000 | 26 | 6' 05" | 330 | Florida | BUF | 23 02 059 | 4 |
| Trujillo, Maddux | PK | 04/12/2003 | 22 | 6' 00" | 170 | Temple | IND FA | 25 CFA | 1 |
| 74 | Van Demark, Ryan | OT | 03/22/1998 | 28 | 6' 06" | 307 | Connecticut | IND FA | 22 CFA | 4 |
| 62 | Van Pran-Granger, Sedrick | C/OG | 10/23/2001 | 24 | 6' 04" | 315 | Georgia | BUF | 24 05 141 | 3 |
| Virgil, Jalen | WR | 07/13/1998 | 27 | 6' 01" | 210 | Appalachian State | DEN FA | 22 CFA | 4 |
| 96 | Walker, Deone | DT | 02/02/2003 | 23 | 6' 07" | 331 | Kentucky | BUF | 25 04 109 | 2 |
| 42 | Williams, Dorian | ILB | 06/08/2001 | 24 | 6' 01" | 228 | Tulane | BUF | 23 03 091 | 4 |
| 19 | Wishnowsky, Mitch | PT | 03/02/1992 | 34 | 6' 02" | 220 | Utah | SF | 19 04 110 | 8 |
| Free Agents / Cap Casualties |
| 97 | Bosa, Joey | OLB | 07/11/1995 | 30 | 6' 05" | 280 | Ohio State | SD | 16 01 003 | 11 |
| 18 | Cooks, Brandin | WR | 09/25/1993 | 32 | 5' 10" | 189 | Oregon State | NO | 14 01 020 | 13 |
| 13 | Davis, Gabe | WR | 04/01/1999 | 26 | 6' 02" | 225 | Central Florida | BUF | 20 04 128 | 7 |
| 57 | Epenesa, A.J. | OLB | 09/15/1998 | 27 | 6' 05" | 260 | Iowa | BUF | 20 02 054 | 7 |
| 3 | Hamlin, Damar | S | 03/24/1998 | 27 | 6' 01" | 200 | Pittsburgh | BUF | 21 06 212 | 6 |
| 23 | Jackson, Dane | CB | 11/29/1996 | 29 | 6' 00" | 180 | Pittsburgh | BUF | 20 07 239 | 6 |
| 92 | Jones, DaQuan | DT | 12/17/1991 | 34 | 6' 04" | 320 | Penn State | TEN | 14 04 112 | 13 |
| 58 | Milano, Matt | ILB | 03/17/1995 | 31 | 6' 00" | 223 | Boston College | BUF | 17 05 163 | 10 |
| 99 | Ogunjobi, Larry | DT | 06/03/1994 | 31 | 6' 02" | 305 | Charlotte | CLE | 17 03 065 | 10 |
| 52 | Phillips, Jordan | DT | 09/21/1992 | 33 | 6' 05" | 341 | Oklahoma | MIA | 15 02 052 | 12 |
| 21 | Poyer, Jordan | S | 04/25/1991 | 34 | 6' 00" | 191 | Oregon State | PHI | 13 07 218 | 14 |
| 15 | Prater, Matt | PK | 08/10/1984 | 41 | 5' 10" | 175 | Central Florida | DET FA | 06 CFA | 20 |
| 9 | Rapp, Taylor | S | 12/22/1997 | 28 | 6' 00" | 208 | Washington | LAR | 19 02 061 | 7 |
| 1 | Samuel, Curtis | WR | 08/11/1996 | 29 | 5' 11" | 195 | Ohio State | CAR | 17 02 040 | 9 |
| Slay, Darius | CB | 01/01/1991 | 35 | 6' 00" | 192 | Mississippi State | DET | 13 02 036 | 13 |
| 54 | Spector, Baylon | ILB | 10/20/1998 | 27 | 6' 01" | 233 | Clemson | BUF | 22 07 231 | 4 |
| 45 | Thompson, Shaq | ILB | 04/21/1994 | 31 | 6' 00" | 230 | Washington | CAR | 15 01 025 | 12 |
| 27 | White, Tre'Davious | CB | 01/16/1995 | 31 | 5' 11" | 192 | LSU | BUF | 17 01 027 | 10 |