| Pick | Team | Player | Pos. | School |
| Round 1 |
| 1 |
Bears
f/CAR
| Caleb Williams | QB | USC |
| 2 |
Commanders
| Jayden Daniels | QB | LSU |
| 3 |
Patriots
| Drake Maye | QB | North Carolina |
| MIN trades 11, 23, 2025 1st to NE for 3 |
| 4 |
Cardinals
| Marvin Harrison Jr. | WR | Ohio State |
| 5 |
Chargers
| Malik Nabers | WR | LSU |
| NYJ Trade 10, 72, 2025 2nd |
| 6 |
Giants
| Rome Odunze | WR | Washington |
| 7 |
Titans
| Joe Alt | OT | Notre Dame |
| 8 |
Falcons
| Quinyon Mitchell | CB | Toledo |
| 9 |
Bears
| Dallas Turner | ED | Alabama |
| 10 |
Jets
| Taliese Fuaga | OT | Oregon State |
| LAC via NYJ |
| 11 |
Vikings
| Olumuyiwa Fashanu | OT | Penn State |
| NE via MIN |
| 12 |
Broncos
| JJ McCarthy | QB | Michigan |
| 13 |
Raiders
| Terrion Arnold | CB | Alabama |
| 14 |
Saints
| JC Latham | OT | Alabama |
| 15 |
Colts
| Brock Bowers | TE | Georgia |
| 16 |
Seahawks
| Troy Fautanu | OG | Washington |
| 17 |
Jaguars
| Brian Thomas Jr. | WR | LSU |
| 18 |
Bengals
| Byron Murphy II | DT | Texas |
| 19 |
Rams
| Jer'Zhan Newton | DT | Illinois |
| 20 |
Steelers
| Amarius Mims | OT | Georgia |
| 21 |
Dolphins
| Graham Barton | OG | Duke |
| 22 |
Eagles
| Cooper DeJean | CB | Iowa |
| 23 |
Vikings
f/CLE
| Laiatu Latu | ED | UCLA |
| NE via MIN |
| 24 |
Cowboys
| Jackson Powers-Johnson | OC | Oregon |
| 25 |
Packers
| Tyler Guyton | OT | Oklahoma |
| 26 |
Buccaneers
| Jared Verse | ED | Florida State |
| 27 |
Cardinals
f/HOU
| Nate Wiggins | CB | Clemson |
| 28 |
Bills
| Adonai Mitchell | WR | Texas |
| 29 |
Lions
| Kool-Aid McKinstry | CB | Alabama |
| 30 |
Ravens
| Ladd McConkey | WR | Georgia |
| 31 |
49ers
| Jordan Morgan | OT | Arizona |
| 32 |
Chiefs
| Xavier Worthy | WR | Texas |