| Pick | Team | Player | Pos. | School |
| Round 1 |
| 1 |
Browns
| Sam Darnold | QB | Southern Cal |
| 2 |
Giants
| Saquon Barkley | RB | Penn State |
| 3 |
Jets
f/IND
| Josh Allen | QB | Wyoming |
| 4 |
Browns
f/HOU
| Bradley Chubb | DE | North Carolina State |
| 5 |
Broncos
| Quenton Nelson | OG | Notre Dame |
| 6 |
Colts
f/NYJ
| Baker Mayfield | QB | Oklahoma |
| Indy trades #6 overall to Arizona for #15, #79 overall (3rd round), and a 2019 5th round pick. |
| 7 |
Buccaneers
| Derwin James | SS | Florida State |
| 8 |
Bears
| Denzel Ward | CB | Ohio State |
| 9 |
49ers
| Minkah Fitzpatrick | CB | Alabama |
| 10 |
Raiders
| Vita Vea | DT | Washington |
| 11 |
Dolphins
| Josh Rosen | QB | UCLA |
| 12 |
Bills
f/BUF
| Lamar Jackson | QB | Louisville |
| 13 |
Commanders
| Da'Ron Payne | DT | Alabama |
| 14 |
Packers
| Roquan Smith | IB | Georgia |
| 15 |
Cardinals
| Mike McGlinchey | OT | Notre Dame |
| Indy |
| 16 |
Ravens
| Calvin Ridley | WR | Alabama |
| 17 |
Chargers
| Tremaine Edmunds | OB | Virginia Tech |
| 18 |
Seahawks
| Maurice Hurst | DT | Michigan |
| 19 |
Cowboys
| DJ Moore | WR | Maryland |
| 20 |
Lions
| Marcus Davenport | DE | Texas-San Antonio |
| 21 |
Bengals
f/CIN
| Connor Williams | OT | Texas |
| 22 |
Bills
f/KC
| Isaiah Wynn | OG | Georgia |
| 23 |
Patriots
f/LAR
| Rashaan Evans | OB | Alabama |
| 24 |
Panthers
| Josh Jackson | CB | Iowa |
| 25 |
Titans
| Harold Landry | OB | Boston College |
| 26 |
Falcons
| Leighton Vander Esch | OB | Boise State |
| 27 |
Saints
| Hayden Hurst | TE | South Carolina |
| 28 |
Steelers
| Jaire Alexander | CB | Louisville |
| 29 |
Jaguars
| Courtland Sutton | WR | SMU |
| 30 |
Vikings
| Billy Price | OC | Ohio State |
| 31 |
Patriots
| Kolton Miller | OT | UCLA |
| 32 |
Eagles
| Mike Gesicki | TE | Penn State |
| Round 2 |
| 33 |
Browns
| Isaiah Oliver | CB | Colorado |
| 34 |
Giants
| Will Hernandez | OG | UTEP |
| 35 |
Browns
f/HOU
| Sony Michel | RB | Georgia |
| 36 |
Colts
| Taven Bryan | DT | Florida |
| 37 |
Colts
f/NYJ
| Mike Hughes | CB | Central Florida |
| 38 |
Buccaneers
| Derrius Guice | RB | LSU |
| 39 |
Bears
| Malik Jefferson | IB | Texas |
| 40 |
Broncos
| Ronald Jones | RB | Southern Cal |
| 41 |
Raiders
| Ronnie Harrison | FS | Alabama |
| 42 |
Dolphins
| Dallas Goedert | TE | South Dakota State |
| 43 |
Patriots
f/SF
| Christian Kirk | WR | Texas A&M |
| 44 |
Commanders
| James Daniels | OC | Iowa |
| 45 |
Packers
| DJ Chark | WR | LSU |
| 46 |
Bengals
| Austin Corbett | OG | Nevada |
| 47 |
Cardinals
| Carlton Davis | CB | Auburn |
| 48 |
Chargers
| Justin Reid | SS | Stanford |
| 49 |
Colts
f/NYJ/SEA
| Nick Chubb | RB | Georgia |
| 50 |
Cowboys
| Mark Andrews | TE | Oklahoma |
| 51 |
Lions
| Kerryon Johnson | RB | Auburn |
| 52 |
Ravens
| Ian Thomas | TE | Indiana |
| 53 |
Bills
| Jamarco Jones | OT | Ohio State |
| 54 |
Chiefs
| Sam Hubbard | DE | Ohio State |
| 55 |
Panthers
| Deon Cain | WR | Clemson |
| 56 |
Bills
f/LAR
| Jerome Baker | OB | Ohio State |
| 57 |
Titans
| Harrison Phillips | DT | Stanford |
| 58 |
Falcons
| Tim Settle | DT | Virginia Tech |
| 59 |
49ers
f/NO
| Arden Key | DE | LSU |
| 60 |
Steelers
| Darius Leonard | IB | South Carolina State |
| 61 |
Jaguars
| Tyrell Crosby | OT | Oregon |
| 62 |
Vikings
| Terrell Edmunds | FS | Virginia Tech |
| 63 |
Patriots
| Anthony Averett | CB | Alabama |
| 64 |
Browns
f/PHI
| Equanimeous St. Brown | WR | Notre Dame |