| 1 | Sun, Sep 06 | vs  12 Mississippi | L 38-41 | L. Kienholz
18/29, 307 yds, 2 TD | L. Kienholz
14 car, 69 yds, 1 TD | T. Richardson
4 rec, 83 yds, 1 TD | Nissan Stadium
Nashville, TN |
| 2 | Fri, Sep 11 | vs  Villanova | W 59-13 | L. Kienholz
16/21, 332 yds, 2 TD | M. Davis
7 car, 86 yds, 2 TD | L. McCoy
3 rec, 102 yds, 1 TD | Cardinal Stadium
Louisville, KY |
| 3 | Sat, Sep 19 | vs  SMU | W 41-31 | L. Kienholz
14/23, 177 yds, 2 TD | K. Brown
10 car, 163 yds, 2 TD | T. Richardson
4 rec, 62 yds | Cardinal Stadium
Louisville, KY |
| 4 | Sat, Sep 26 | vs  14 Wake Forest | L 27-30 | L. Kienholz
27/36, 324 yds, 1 TD, 1 INT | K. Brown
12 car, 48 yds | T. Richardson
5 rec, 85 yds | Cardinal Stadium
Louisville, KY |
| 6 | Fri, Oct 09 | vs  Florida State | W 44-20 | L. Kienholz
11/15, 140 yds | I. Brown
17 car, 235 yds, 2 TD | L. McCoy
3 rec, 78 yds | Cardinal Stadium
Louisville, KY |
| 7 | Sat, Oct 17 | @  Syracuse | W 34-26 | L. Kienholz
14/26, 310 yds, 1 TD, 2 INT | L. Kienholz
10 car, 53 yds, 2 TD | L. McCoy
5 rec, 93 yds | Carrier Dome
Syracuse, NY |
| 8 | Sat, Oct 24 | Open Date | | | | |
|
| 9 | Sat, Oct 31 | vs  Stanford | W 52-24 | L. Kienholz
20/28, 250 yds, 2 TD | I. Brown
9 car, 139 yds, 3 TD | T. Richardson
10 rec, 140 yds | Cardinal Stadium
Louisville, KY |
| 10 | Sat, Nov 07 | @  Georgia Tech | | | | | Bobby Dodd Stadium
Atlanta, GA |
| 11 | Sat, Nov 14 | @  North Carolina | | | | | Kenan Stadium
Chapel Hill, NC |
| 12 | Sat, Nov 21 | vs  Pittsburgh | | | | | Cardinal Stadium
Louisville, KY |
| 13 | Sat, Nov 28 | @  8 Kentucky | | | | | Kroger Field
Lexington, KY |
| 14 | Sat, Dec 05 | Open Date | | | | |
|