| 1 | Fri, Sep 04 | vs  Toledo | W 30-20 | Spartan Stadium
East Lansing, MI |
| 2 | Sat, Sep 12 | vs  Eastern Michigan | W 35-7 | Spartan Stadium
East Lansing, MI |
| 3 | Sat, Sep 19 | @  4 Notre Dame | L 10-27 | Notre Dame Stadium
South Bend, IN |
| 4 | Sat, Sep 26 | vs  Nebraska | L 13-31 | Spartan Stadium
East Lansing, MI |
| 5 | Sat, Oct 03 | @  Wisconsin | L 3-31 | Camp Randall Stadium
Madison, WI |
| 6 | Sat, Oct 10 | vs  Illinois | L 37-38 | Spartan Stadium
East Lansing, MI |
| 7 | Sat, Oct 17 | vs  24 Northwestern | L 21-24 | Spartan Stadium
East Lansing, MI |
| 8 | Sat, Oct 24 | @  9 UCLA | | Rose Bowl
Pasadena, CA |
| 9 | Sat, Oct 31 | Open Date | |
|
| 10 | Sat, Nov 07 | @  Michigan | | Michigan Stadium
Ann Arbor, MI |
| 11 | Sat, Nov 14 | vs  Washington | | Spartan Stadium
East Lansing, MI |
| 12 | Fri, Nov 20 | vs  Oregon | | Spartan Stadium
East Lansing, MI |
| 13 | Sat, Nov 28 | @  Rutgers | | SHI Stadium
Piscataway, NJ |
| 14 | Sat, Dec 05 | Open Date | |
|