| Pick | Team | Player | Pos. | School |
| Round 1 |
| 1 |
Jaguars
| Trevor Lawrence | QB | Clemson |
| 2 |
Jets
| Zach Wilson | QB | BYU |
| The Jets trade Darnold to the Steelers for a 2022 2nd rnd pick. The Steelers decide to move on from Big Ben. |
| 3 |
Dolphins
f/HOU
| Ja'Marr Chase | WR | LSU |
| 4 |
Falcons
| Caleb Farley | CB | Virginia Tech |
| 5 |
Bengals
| Micah Parsons | IB | Penn State |
| 6 |
Eagles
| Penei Sewell | OT | Oregon |
| 7 |
Lions
| Justin Fields | QB | Ohio State |
| The Lions trade Goff to Carolina for QB Bridgewater and the #8 pick. |
| 8 |
Panthers
| DeVonta Smith | WR | Alabama |
| The Jets make this pick after trading QB Goff to Carolina. |
| 9 |
Broncos
| Patrick Surtain II | CB | Alabama |
| 10 |
Cowboys
| Kwity Paye | DE | Michigan |
| 11 |
Giants
| Kyle Pitts | TE | Florida |
| 12 |
49ers
| Rashawn Slater | OT | Northwestern |
| 13 |
Chargers
| Christian Darrisaw | OT | Virginia Tech |
| 14 |
Vikings
| Christian Barmore | DT | Alabama |
| 15 |
Patriots
| Mac Jones | QB | Alabama |
| 16 |
Cardinals
| Jaylen Waddle | WR | Alabama |
| 17 |
Raiders
| Jeremiah Owusu-Koramoah | OB | Notre Dame |
| 18 |
Dolphins
| Zaven Collins | IB | Tulsa |
| 19 |
Football Team
| Trey Lance | QB | North Dakota State |
| 20 |
Bears
| Teven Jenkins | OT | Oklahoma State |
| 21 |
Colts
| Gregory Rousseau | DE | Miami |
| 22 |
Titans
| Samuel Cosmi | OT | Texas |
| 23 |
Jets
f/SEA
| Jaelan Phillips | DE | Miami |
| 24 |
Steelers
| Alijah Vera-Tucker | OG | Southern Cal |
| 25 |
Jaguars
f/LAR
| Trevon Moehrig | FS | TCU |
| 26 |
Browns
| Nick Bolton | OB | Missouri |
| 27 |
Ravens
| Rashod Bateman | WR | Minnesota |
| 28 |
Saints
| Kadarius Toney | WR | Florida |
| 29 |
Bills
| Jaycee Horn | CB | South Carolina |
| 30 |
Packers
| Rondale Moore | WR | Purdue |
| 31 |
Chiefs
| Jayson Oweh | DE | Penn State |
| 32 |
Buccaneers
| Azeez Ojulari | OB | Georgia |